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Cell viability is an essential measurement for cell therapy, tissue-engineered medical products (TEMPs), drug development, and many other biological processes and products. These systems rely on viable, healthy, and functional cells ...

We're excited to introduce a Transportable Lightweight Small Animal Physiological Monitor, LiteAPMTM, a compact and portable solution designed to bring peace of mind and precision to your small animal experiments. This all-in-one system ...

Did you know that BBB leakage can be quantified non-invasively with EPR Imaging? In a healthy brain, the EPR imaging contrast agent, trityl OXO71, is blocked by the blood-brain barrier ...

As OXO71-based Electron Paramagnetic Resonance Oxygen Imaging (EPROI) transitions from small to large animal models, and ultimately to humans, various challenges must be addressed. Long acquisition times and low SNR of ...

About the Speaker: Dr. Buehler is a pharmacologist and toxicologist who utilizes both applied and mechanistic approaches to understand aberrant red blood cell biology. In 2019 he moved his laboratory from ...

Type 1 diabetes (T1D) is an autoimmune disease that leads to the loss of insulin-producing pancreatic beta cells. Beta cell replacement devices or bioartificial pancreas (BAP) have shown promise in ...

Cancer is a major public health problem worldwide and is the second leading cause of death in the United States. About two-thirds of cancer patients are treated with radiation, either ...

Magnetic resonance imaging (MRI) and electron paramagnetic resonance oxygen imaging (eMRI or EPROI) are fundamentally based upon the same principles, however a key difference is the resonant species. MRI aligns ...

Oxygen sensitive LiPc probes implanted within the right dorsum subcutaneously, reporting oxygen tension over 6 weeks. Data obtained by JIVA-25™ oxygen imager. Tissue engineered grafts and cell encapsulation devices have ...

Biomaterials that host live cells must overcome the crucial hurdle of sustaining sufficient oxygenation for cell survival. Several approaches for improving oxygenation within the biomaterials have been developed and investigated for ...

This spring, O2M is hosting a webinar mini-series on cancer hypoxia! Join us next month for a conversation with Duke University team Drs. Greg Palmer, Yvone Mowery, & Ashlyn Rickard, investigating how oxygen ...

Fibrosarcoma in mouse leg encircled in purple. A) MRI, B) EPROI C) Uniform radiation dose D) Radiation dosed by regional hypoxia Radiation therapy is a dual-edged sword, capable of destroying ...

Moderator: Dr. Benoit Driesschaert, West Virginia UniversityAbout the Speaker:Dr. Tseytlin grew up in a family of medical doctors (four generations now) but had a taste for physics, mathematics, and engineering. After ...

Type 1 diabetes mellitus (T1D) is an autoimmune disease causing insufficient or no production of insulin from the pancreas; this impedes glucose metabolism, generating several life-long health sequelae in nearly ...

Come meet Team O2M at RSNA 2021! Our Demo JIVA-25 allows you to capture oxygen images of a "mouse." We are located in the New Vendors Exhibition Hall, booth #2402.

Inadequate oxygenation is a major challenge in cell encapsulation, a therapy which holds potential to treat many diseases including type I diabetes. In such systems, cellular oxygen (O2) delivery is ...

Axial slices of SCC7 squamous cell carcinoma in mouse leg of MRI, PO2 by JIVA-25™, and CT. Tumor contoured in pink. Photo credit: Howard Halpern Lab, The University of Chicago ...

The 2019 Nobel Prize in medicine for the discovery of oxygen signaling pathways highlights the importance of oxygenation as a physiologic parameter. Oxygenation, the delivery of oxygen to cells and ...

Moderated by: Dr. Boris Epel, University of Chicago About the Speaker: Dr. Kuppusamy is a tenured Professor in the Departments of Radiology and Medicine at the Geisel School of Medicine, Dartmouth College. ...

Moderated by: Dr. Benoit Driesschaert, West Virginia University About the Speaker:Gareth R. Eaton received his A.B. at Harvard and obtained his Ph.D. at MIT 1972. Since then he has been in ...

O2M's "Oxygen Measurement Core" is a contract research facility. It provides full cycle in vitro and small animal in vivo oxygen measurement services. All experiments are performed using O2M's preclinical oxygen imager, JIVA-25™ that ...

Moderated by: Dr. Howard Halpern, University of Chicago About the Speaker: Dr. Biller is a Principal Chemist at TDA Research, Inc. in Golden, CO. He graduated from the Eaton Laboratory at the ...

Cell encapsulation represents a promising therapeutic strategy for many hormone-deficient diseases such as type I diabetes (T1D). However, adequate oxygenation of the encapsulated cells remains a challenge, especially in the ...

Did you know that JIVA-25™ can provide in vivo partial oxygen pressure (pO2) maps of an implanted devices in a rodent? The pO2 maps provide a crucial missing information to ...

About the Speaker: Dr. Benoit Driesschaert is an Organic Chemist, Assistant Professor at West Virginia University in the Department of Pharmaceutical Sciences. His laboratory develops stable triarylmethyl radicals used as spin ...

Did you know that JIVA-25™ can provide in vivo partial oxygen pressure (pO2) maps of an implanted devices in a rodent? The pO2 maps provide a crucial missing information to ...

About the Speaker: Harold Swartz MD, PhD, MSPH, has held the Alma Hass Milham Distinguished Chair in Clinical Medicine and has been the director of the Electron Paramagnetic Resonance (EPR) Centers ...

Rapid Fire Presentations 558: In Vitro pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core  (In collaboration with the University of Chicago, University of Arizona, Cornell University, University of Florida, and ...

Moderated by: Carl G. Simon, Jr., Ph.D., National Institute of Standards and Technology (NIST) About the Speaker: Dr. Kotecha is a founding member and CEO of O2M technologies. She graduated from the ...

Moderated By: Dr. Mark Dewhirst, Duke University About the Speaker: Greg Palmer obtained his B.S. in Biomedical Engineering from Marquette University in 2000, after which he obtained his Ph.D. in BME from the ...

About the Speaker: Dr. Halpern is a Professor of Radiation and Cellular Oncology and Director (PI) of the NIH Center for EPR Imaging In Vivo Physiology at the University of Chicago ...

Hypoxia severely limits the efficacy of radiotherapy, chemotherapy, and immunotherapy. This results in diminished success in treating cancer. Despite consistent research in this field and treatments with promising anti-hypoxia mechanisms, ...

Spatial heterogeneity in tumor hypoxia is one of the most important factors regulating tumor growth, development, aggressiveness, metastasis, and effective treatment outcome. Most solid tumors are characterized by hypoxia or ...

About the Speaker: Our first speaker is Dr. Boris Epel, Research Professor of the Department of Radiation and Cellular Oncology, University of Chicago. Dr. Epel is one of the inventors ...