Frequently Asked Questions
Oxygen imaging is a technology that generates partial oxygen pressure (pO₂) maps of tissues in vitro and in vivo. O2M's patented oxygen imaging technology is based on pulse electron paramagnetic resonance oxygen imaging (EPROI). EPROI provides fast three-dimensional pO₂ maps non-invasively with high precision and high resolution. Oxygen imaging gives complete oxygen distribution and is distinct from pulse oximetry, polarographic electrodes, or oxygen-quenching luminescence sensors, which provide single point pO₂ values at the location of the probe.
Electron paramagnetic resonance (EPR) is a magnetic resonance technique to detect unpaired electron spins of a molecule placed intro a magnetic field by applying radiofrequency electromagnetic field.
EPR oxygen imaging (EPROI) is an established noninvasive method to map absolute oxygen values within ~0.5 mm resolution. EPROI measures electron spin relaxation maps of a water-soluble oxygen-reporting trityl OX071 molecule. Trityl spin probes have an unpaired electron which directly collides with valence electrons in molecular oxygen. This interaction changes the spin-spin- and spin-lattice relaxation rate of the probe by Heisenberg spin exchange. There is a linear relationship between pO2 and trityl relaxation rates. This linear relationship is used for mapping oxygen, which is the basis of EPROI.
JIVA-25™ is a first-of-a-kind preclinical oxygen imager. JIVA-25™ provides three-dimensional oxygen maps. Biomaterial samples, cell encapsulation devices, artificial tissue grafts, and small rodents can be imaged with JIVA-25™. The maximum object size that fits into volume resonator is about 32 mm in diameter and 35 mm in length. Surface oxygen maps of the objects up to 10 cm in diameter can be obtained using surface coils.
JIVA-25™ provides both average oxygen over the sample volume as well as three dimensional oxygen maps.
Yes. JIVA-25™ can measure oxygen in various biomaterials so long as there is no metal component. The examples include but are not limited to, gelatin, agarose, alginate, etc.
Samples can be as small as 400µg of cell suspension to as large as 40g small rodents.
JIVA-25™ can not perform oxygen imaging in humans.
CAELI-9™ is a 9 mT human-size prototype under development. Currently, it is not available for purchase.
We have several collaborative projects in the US and abroad. You can read our recent publications here.
25 milliTesla (mT).