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O2M Will Build the World’s First Clinical Oxygen Imager

The 2019 Nobel Prize in medicine for the discovery of oxygen signaling pathways highlights the importance of oxygenation as a physiologic parameter. Oxygenation, the delivery of oxygen to cells and tissues, plays a key role in cancer development and aggressiveness. Tumors have a highly heterogeneous oxygen environment and low oxygenation - hypoxia - is an obstacle to cancer therapy. Cancer cells that manage to survive in low-oxygen environments can evade chemotherapy & radiation therapy, and are more likely to become metastatic. For these reasons, tumor hypoxia is a well-recognized prognostic indicator for cancer, demonstrated to have an adverse effect on soft tissue sarcomas, head and neck cancer, and many other cancer types. However, currently clinicians do not have access to a quantitative human-sized oxygen imaging instrument.


O2M Technologies, founded by Dr. Mrignayani Kotecha, Dr. Boris Epel, and Dr. Howard Halpern, recently received an NIH/NCI SBIR Phase I grant to build the first of it’s kind human oxygen imager prototype, named CAELI-9. CAELI-9 will utilize a 9 mT human size magnet to generate low-field electron paramagnetic resonance images, delivering actual-value images of oxygen tension in tumor tissue with high precision.  Mapping tumor oxygenation noninvasively in real timewould be a powerful tool in radiotherapy guidance. CAELI-9 can be integrated into the cancer care workflow. This technology would open the way to develop more targeted therapies and new treatment strategies for cancer.

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O2M’s Oxygen Measurement Core

O2M’s "Oxygen Measurement Core" is a contract research facility. It provides full cycle in vitro and small animal in vivo oxygen measurement services. All experiments are performed using O2M’s preclinical oxygen imager, JIVA-25™ that can accommodate sample size up to 40 mm. O2M can carry research projects to its full  experiment cycle, from sample preparation and cell seeding to in vitro and small animal in vivo oxygen imaging along with biologic assays and histology assessments, and provide publication quality data/images, and support your submission to peer reviewed journals leading up to publication of the work. The current projects are in the field of tissue engineering regenerative medicine, cancer, and type I diabetes, and we are interested in other areas where oxygen measurements could provide useful insights in biology, metabolism, drug, and therapy development.

Example projects:

  1. In vitro longitudinal (hours/days) oxygen assessment of acellular and cell loaded biomaterials, tissue grafts, and cell encapsulation devices
  2. In vivo small animal  longitudinal (days/weeks/months) assessment of biomaterials, tissue grafts, and cell encapsulation devices
  3. In vivo oxygen assessment of tumor growth and response to treatments
  4. Development of efficient oxygen guided tumor therapies

Example samples:

  1. Biomaterials: Gelatin, Alginate, Agarose, Collagen, Chitosan, PLGA, and other combination experimental biomaterials
  2. Cell encapsulation devices: flat sheet, oxygen generating,3D printed vascular devices
  3. Small animal tumor models

O2M’s clients are academic institutions, research foundations, and industry partners.

Reach out to us to discuss your research project!

Oxygen diffusion in biomaterials: fresh vs refrigerated gelatin
Oxygen diffusion in biomaterials: fresh vs refrigerated gelatin

See our recent publication featuring data from O2M's Oxygen Measurement Core:


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