Research
Oxygen Measurement Core
O2M’s "Oxygen Measurement Core" is a contract research facility. It provides full cycle in vitro and small animal in vivo oxygen measurement services.
All experiments are performed using O2M’s preclinical oxygen imager, JIVA-25®, that can accommodate sample size up to 40 mm.
O2M can carry research projects to its full experimental cycle, from sample preparation and cell seeding to in vitro and small animal in vivo oxygen imaging.
O2M can also provide biologic assays and histology assessments, publication quality data/images, and support your submission to peer reviewed journals leading up to publication of the work.
O2M’s clients are academic institutions, research foundations, and industry partners. See our recent publications from Oxygen Measurement Core as an example.
Example Projects
- In vitro longitudinal (hours/days) oxygen assessment of acellular and cell loaded biomaterials, tissue grafts, and cell encapsulation devices
- In vivo small animal longitudinal (days/weeks/months) assessment of biomaterials, tissue grafts, and cell encapsulation devices
- In vivo oxygen assessment of tumor growth and response to treatments
- In vivo quantification of blood-brain barrier (BBB) leakage and brain pO2
- Ex vivo oxygen imaging of transplanted organs for viability assessment
Three-dimensional pO2 map of a transplanted mouse liver. The liver appears with smaller pO2 compared to the surrounding oxygenated media, indicating oxygen consumption and therefore live cells.
In vivo oxygen imaging of implanted OxySite device.
Example Samples
- Biomaterials: Gelatin, Alginate, Agarose, Collagen, Chitosan, PLGA, and other combination experimental biomaterials
- Cell encapsulation devices: flat sheet, oxygen generating, 3D printed vascular devices
- Small animal tumor models
Key Publications
Accelerated EPR imaging using deep learning denoising
Magnetic Resonance in Medicine - Volume 94, Issue 1, 2025
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
JoVE Journal, 2025
Composite spin probes with adjustable oxygen sensitivity for pulse electron paramagnetic resonance imaging
Magnetic Resonance in Medicine - Volume 93, Issue 5, 2025
In Vivo Mouse Abdominal Oxygen Imaging And Assessment of Subcutaneously Implanted Beta Cell Replacement Devices
Molecular Imaging and Biology - Volume 27, 2025
For a full list of our publications, see our Publications page
Ethics and Governance
O2M Technologies upholds the highest standards of ethical conduct in all our activities. We and our research partners follow all relevant laws and guidelines, including best practices for the responsible use of animals in biomedical research, as set by AAALAC and AALAS. Our work is supported by thorough team training, quality assurance, and integrated data management. We are committed to transparency, including disclosing potential conflicts of interest, and ensure compliance with requirements for government-funded and sponsored research through a clear Financial Conflict of Interest in Research (FCOIR) policy (click here to view PDF).