Publications - O2M Technologies

The "Molecular Imaging and Biology" journal released a special issue on EPR imaging and its applications to Biomedical Science on the 80th anniversary of EPR. O2M's contribution made it to the cover page art of this issue with the paper "Oxygen Imaging of a Rabbit Tumor Using a Human-Sized Pulse Electron Paramagnetic Resonance Imager". 2D axial and sagittal pO2 maps of the tumor from EPR imaging overlayed on MRI (tumor marked in magenta) are shown on the right panel.

Click here to access the paper!

Awards

Society For Biomaterials Award Winners
January 2024 - Dr. Kotecha and the O2M team received the C. William Hall award for the development of JIVA-25 EPROI instrument, which is the first technology capable to accurately map oxygen distribution in tissue engineered medical products (TEMPs).

Peer Reviewed Publications

Molecular Imaging and Biology (MIB) special issue on EPR
Volume 26, Issue 3 - Featuring our JIVA-25TM
Nondestructive, longitudinal, 3D oxygen imaging of cells in a multi-well plate using pulse electron paramagnetic resonance imaging
Nature - npj Imaging
Measurement Needs for Biofabrication of Tissue Engineered Medical Products
NIST Special Publication
Assessment of blood–brain barrier leakage and brain oxygenation in Connexin-32 knockout mice with systemic neuroinflammation using pulse electron paramagnetic resonance imaging techniques
Magnetic Resonance in Medicine
EPR Imaging and Application to Biomedical Sciences: On the 80th Anniversary of the Discovery of EPR
Molecular Imaging and Biology
Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression
Nature Biomedical Engineering
SOX71, A Biocompatible Succinyl Derivative of the Triarylmethyl Radical OX071 for In Vivo Quantitative Oxygen Mapping Using Electron Paramagnetic Resonance
Molecular Imaging and Biology Journal, 2023
Toward a Nanoencapsulated EPR Imaging Agent for Clinical Use
Molecular Imaging and Biology Journal, 2023
Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models
Frontiers in Medicine, Sec. Nuclear Medicine, 2023
EPRI sparse reconstruction method based on deep learning
Magnetic Resonance Imaging, Volume 97, 2023
Pulse and CW EPR Oximetry Using Oxychip in Gemcitabine-Treated Murine Pancreatic Tumors
Molecular Imaging and Biology Journal, 2023
Oxygen Imaging of a Rabbit Tumor Using a Human‑Sized Pulse Electron Paramagnetic Resonance Imager
Molecular Imaging and Biology Journal, 2023
Evaluating Tumor Hypoxia Radiosensitization Via Electron Paramagnetic Resonance Oxygen Imaging (EPROI)
Molecular Imaging and Biology Journal, 2023
In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
Scientific Reports 13, Article number: 15641, 2023
Tissue-mimetic culture enhances mesenchymal stem cell secretome capacity to improve regenerative activity of keratinocytes and fibroblasts in vitro
Wound Rep Reg. 2023
HIF-Stabilizing Biomaterials: From Hypoxia Mimicking to Hypoxia-Inducing
Material Advances Royal Society of Chemistry, 2023
In Vivo pO2 Assessment in Subcutaneous and Intraperitoneal sites Using Imaging of Solid Oxygen Probe
Tissue Engineering Part C: Methods, 2022
An Iterative Reconstruction Algorithm Without System Matrix for EPR Imaging
Journal of Magnetic Resonance, 2022
Amniotic growth factors enhanced human pre-adipocyte cell viability and differentiation under hypoxia
Journal of Biomedical Materials Research Part B, 2022
A Bioinspired Scaffold for Rapid Oxygenation of Cell Encapsulation
Nature Communications, 2021
An Inverse-Breathing Encapsulation System for Cell Delivery
Science Advances, 2021
Noninvasive Absolute Electron Paramagnetic Resonance Oxygen Imaging for the Assessment of Tissue Graft Oxygenation
Tissue Engineering: Part C, 2018
In Vivo EPR Oxygen Imaging: A Case for Tissue Engineering
Magnetic Resonance Imaging in Tissue Engineering, First Edition. Edited by Mrignayani Kotecha, 2017

Conference Presentations

Behind BBB: Trityl based Oxygen Imaging of Systemic Neuroinflammation in Mice, oral presentation
Rocky Mountain EPR Symposium, Denver 2023
Assessment of Blood-Brain-Barrier Leakage and Brain Oxygenation in Connexin-32 Knockout Mice with Systemic Neuroinflammation Using EPR Imaging
Rocky Mountain EPR Symposium, Denver 2023
Nondestructive, Longitudinal, 3D Cell Viability Assessment in a Multi-Well Plate System Using EPR Oxygen Imaging
Rocky Mountain EPR Symposium, Denver 2023
Assessment of Blood-Brain-Barrier Leakage and Brain Oxygenation in Connexin-32 Knockout Mice with Systemic Neuroinflammation Using EPR Imaging
Gordon Research Conference, Stonehill College, 2023.
Whole Body Mouse EPR Oxygen Imaging of Implanted Beta Cell Replacement Devices
International Society for Magnetic Resonance in Medicine Annual Meeting, Toronto, Canada, June 3-8, 2023.
Nondestructive, Longitudinal, 3D Cell Viability Assessment in a Multi-Well Plate System Using EPR Oxygen Imaging
EPR 2023 International Conference on EPR Spectroscopy and Imaging of Biological Systems, May 22-26, 2023, Paris, France.
Assessment of Blood-Brain-Barrier Leakage and Brain Oxygenation in Connexin-32 Knockout Mice with Systemic Neuroinflammation Using EPR Imaging
EPR 2023 International Conference on EPR Spectroscopy and Imaging of Biological Systems, May 22-26, 2023, Paris, France
Rabbit Tumor Oxygen Imaging Using Human-Size 9 mT pulse EPR Imager
EPR 2023 International Conference on EPR Spectroscopy and Imaging of Biological Systems, May 22-26, 2023, Paris, France.
Nondestructive in situ oxygen consumption rate assessment in a multi-well system using EPR oxygen imaging
Stem cell-derived beta cell, 4^th International Pancreas & Islet Transplant Association (IPITA) meeting, Boston, April 24-25, 2023.
EPR Oxygen Imaging of Beta Cell Replacement Devices for Type Diabetes Cure
18^th European Society for Molecular Imaging Meeting, Salzburg, Austria.
Nondestructive Real-Time Cell Viability Assessment Using EPR Oxygen Imaging
18^th European Society for Molecular Imaging Meeting, Salzburg, Austria.
A 25 mT Preclinical Electron Paramagnetic Resonance Oxygen Imager, JIVA-25, And Its Applications to Small Animal Image-Guided Radiotherapy
5th Conference on Small Animal Precision Image-Guided Radiotherapy, March 21-23, 2022, Munich, Germany.
In Vivo Oxygen Imaging of Implanted Islet Encapsulation Devices
International Society for Magnetic Resonance in Medicine Annual Meeting, 7-12 May 2022, London, UK.
In Vivo pO2 Assessment of Implantation sites Using Solid Probe Oxygen Imaging
Annual meeting of Society For Biomaterials, Baltimore, April 27-30, 2022, Baltimore.
In Vivo pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core
Annual meeting of Society For Biomaterials, Baltimore, April 27-30, 2022, Baltimore.
A 25 mT Preclinical Electron Paramagnetic Resonance Oxygen Imager and Its Applications to Biomedical Studies
World Molecular Imaging Society Annual Meeting, Sept 28-Oct 1^st, 2022, Miami, Florida.
Directing Local Hypoxia Radiation Boosts in a Third Tumor Model, SCC7 Squamous Cell Carcinomas, with Low- and High-frequency EPR pO2 Imaging
Radiological Society of North America (RSNA), Dec 2021, Chicago.
In Vitro pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core
Society of Biomaterials annual meeting, Chicago (cancelled due to COVID), April 20-23, 2021.
Methodology for Biomaterial Oxygen Imaging Using Trityl Based Pulse Electron Paramagnetic Resonance
Society of Biomaterials annual meeting, Chicago, April 20-23, 2021.
Trityl Radical OX071, an EPR Oxygen Imaging Spin Probe, Is Non-Toxic to Cells
Society of Biomaterials annual meeting, Chicago, April 20-23, 2021.
Preclinical Oxygen Imager for Cancer Oxygenation Studies
American Association for Cancer Research (AACR) Annual Meeting, April 24-29, 2020.
Oxygen Imaging of Biomaterials
World Biomaterial Congress, Oral virtual presentation, Dec 11-15, 2020.
Introducing 3D oxygen imaging via electron paramagnetic resonance for radiation biology applications
Radiation Research Society, Nov 2020.
Absolute EPR Oxygen Imaging for the Assessment of Oxygen Pressure and Local Oxygen Consumption Rate in Tissue Grafts
American Association of Chemical Engineers Midwest meeting, Feb 28- March 1^st, 2017, Chicago, IL.
Probing Oxygen Tension of Tissue Engineered Grafts using Oxygen Imaging
Society for Biomaterials Annual Meeting, April 6^th, 2017, Minneapolis, MN.
Investigating Oxygen Dynamics of Stem Cells in a Mineralized Osteogenic Scaffold
Society for Biomaterials Annual Meeting, April 8^th, 2017, Minneapolis, MN.
In Vitro and In Vivo Oxygen Imaging of Islet Encapsulation Devices: Lessons Learned and the Road Forward
BioFab USA, 2022
In Vivo Oxygen Imaging of Implanted Encapsulated Islet Devices
International Society for Magnetic Resonance in Medicine, 2022
In Vivo pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core
Society for Biomaterials, 2022
In Vivo pO2 Assessment of Implantation sites Using Solid Probe Oxygen Imaging
Society for Biomaterials, 2022
Methodology for Biomaterial Oxygen Imaging Using Trityl Based Pulse Electron Paramagnetic Resonance
Society for Biomaterials, 2021
Trityl Radical OX071, an EPR Oxygen Imaging Spin Probe, Is Non-Toxic to Cells
Society for Biomaterials, 2021
In Vitro pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core
Society for Biomaterials, 2021
A 25 mT Preclinical Electron Paramagnetic Resonance Oxygen Imager, JIVA-25Ô, And Its Applications to Small Animal Image-Guided Radiotherapy
4th Conference on Small Animal Precision Image-Guided Radiotherapy, 2021
Directing Local Hypoxia Radiation Boosts in a Third Tumor Model, SCC7 Squamous Cell Carcinomas, with Low- and High-frequency EPR pO2 Imaging
Radiological Society of North America, 2021
Preclinical Oxygen Imager for Cancer Oxygenation Studies
American Association for Cancer Research, 2020
Oxygen Imaging as A Quality Control Tool in Tissue Manufacturing
BioFab USA, 2019
Oxygen Imaging of Biomaterials
Society for Biomaterials, 2020
Oxygen Imaging of Common Biomaterials
Tissue Engineering and Regenerative Medicine International Society (TERMIS-AM) annual meeting, Dec 2-5, 2019, Orlando, FL.
Oxygen Imaging as a Quality Control Tool in Tissue Manufacturing
BioFab USA Summit, 2019

Awards

Society For Biomaterials Award Winners

Peer Reviewed Publications

In Vivo pO2 Assessment in Subcutaneous and Intraperitoneal sites Using Imaging of Solid Oxygen Probe

Amniotic growth factors enhanced human pre-adipocyte cell viability and differentiation under hypoxia

A Bioinspired Scaffold for Rapid Oxygenation of Cell Encapsulation

An Inverse-Breathing Encapsulation System for Cell Delivery

Noninvasive Absolute Electron Paramagnetic Resonance Oxygen Imaging for the Assessment of Tissue Graft Oxygenation

In Vivo EPR Oxygen Imaging: A Case for Tissue Engineering

Conference Presentations

Behind BBB: Trityl based Oxygen Imaging of Systemic Neuroinflammation in Mice, oral presentation

Assessment of Blood-Brain-Barrier Leakage and Brain Oxygenation in Connexin-32 Knockout Mice with Systemic Neuroinflammation Using EPR Imaging

Nondestructive, Longitudinal, 3D Cell Viability Assessment in a Multi-Well Plate System Using EPR Oxygen Imaging

Assessment of Blood-Brain-Barrier Leakage and Brain Oxygenation in Connexin-32 Knockout Mice with Systemic Neuroinflammation Using EPR Imaging

Whole Body Mouse EPR Oxygen Imaging of Implanted Beta Cell Replacement Devices

Nondestructive, Longitudinal, 3D Cell Viability Assessment in a Multi-Well Plate System Using EPR Oxygen Imaging

Assessment of Blood-Brain-Barrier Leakage and Brain Oxygenation in Connexin-32 Knockout Mice with Systemic Neuroinflammation Using EPR Imaging

Rabbit Tumor Oxygen Imaging Using Human-Size 9 mT pulse EPR Imager

Nondestructive in situ oxygen consumption rate assessment in a multi-well system using EPR oxygen imaging

EPR Oxygen Imaging of Beta Cell Replacement Devices for Type Diabetes Cure

Nondestructive Real-Time Cell Viability Assessment Using EPR Oxygen Imaging

A 25 mT Preclinical Electron Paramagnetic Resonance Oxygen Imager, JIVA-25, And Its Applications to Small Animal Image-Guided Radiotherapy

In Vivo Oxygen Imaging of Implanted Islet Encapsulation Devices

In Vivo pO2 Assessment of Implantation sites Using Solid Probe Oxygen Imaging

In Vivo pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core

A 25 mT Preclinical Electron Paramagnetic Resonance Oxygen Imager and Its Applications to Biomedical Studies

Directing Local Hypoxia Radiation Boosts in a Third Tumor Model, SCC7 Squamous Cell Carcinomas, with Low- and High-frequency EPR pO2 Imaging

In Vitro pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core

Methodology for Biomaterial Oxygen Imaging Using Trityl Based Pulse Electron Paramagnetic Resonance

Trityl Radical OX071, an EPR Oxygen Imaging Spin Probe, Is Non-Toxic to Cells

Preclinical Oxygen Imager for Cancer Oxygenation Studies

Oxygen Imaging of Biomaterials

Introducing 3D oxygen imaging via electron paramagnetic resonance for radiation biology applications

Absolute EPR Oxygen Imaging for the Assessment of Oxygen Pressure and Local Oxygen Consumption Rate in Tissue Grafts

Probing Oxygen Tension of Tissue Engineered Grafts using Oxygen Imaging

Investigating Oxygen Dynamics of Stem Cells in a Mineralized Osteogenic Scaffold

In Vitro and In Vivo Oxygen Imaging of Islet Encapsulation Devices: Lessons Learned and the Road Forward

In Vivo Oxygen Imaging of Implanted Encapsulated Islet Devices

In Vivo pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core

In Vivo pO2 Assessment of Implantation sites Using Solid Probe Oxygen Imaging

Methodology for Biomaterial Oxygen Imaging Using Trityl Based Pulse Electron Paramagnetic Resonance

Trityl Radical OX071, an EPR Oxygen Imaging Spin Probe, Is Non-Toxic to Cells

In Vitro pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core

A 25 mT Preclinical Electron Paramagnetic Resonance Oxygen Imager, JIVA-25Ô, And Its Applications to Small Animal Image-Guided Radiotherapy

Directing Local Hypoxia Radiation Boosts in a Third Tumor Model, SCC7 Squamous Cell Carcinomas, with Low- and High-frequency EPR pO2 Imaging

Preclinical Oxygen Imager for Cancer Oxygenation Studies

Oxygen Imaging as A Quality Control Tool in Tissue Manufacturing

Oxygen Imaging of Biomaterials

Oxygen Imaging of Common Biomaterials

Oxygen Imaging as a Quality Control Tool in Tissue Manufacturing