Our Services

Oxygen Measurement Core

O2M’s "Oxygen Measurement Core" is a contract research facility. It provides full cycle in vitro and small animal in vivo oxygen measurement services.

All experiments are performed using O2M’s preclinical oxygen imager, JIVA-25™, that can accommodate sample size up to 40 mm.
O2M can carry research projects to its full experimental cycle, from sample preparation and cell seeding to in vitro and small animal in vivo oxygen imaging.
O2M can also provide biologic assays and histology assessments, publication quality data/images, and support your submission to peer reviewed journals leading up to publication of the work.
O2M’s clients are academic institutions, research foundations, and industry partners. See our recent publications from Oxygen Measurement Core as an example.

Reach out to us to discuss your research project!

Example Projects and Samples

Example Projects

  • In vitro longitudinal (hours/days) oxygen assessment of acellular and cell loaded biomaterials, tissue grafts, and cell encapsulation devices
  • In vivo small animal longitudinal (days/weeks/months) assessment of biomaterials, tissue grafts, and cell encapsulation devices
  • In vivo oxygen assessment of tumor growth and response to treatments
acellular v cellular

pO₂ maps as a function of time of a macro-encapsulation device with a channel for media flow in the center.

subQ islet in vivo map

In vivo pO₂ maps of an islet encapsulation device implanted subcutaneously.

Example Samples

  • Biomaterials: Gelatin, Alginate, Agarose, Collagen, Chitosan, PLGA, and other combination experimental biomaterials
  • Cell encapsulation devices: flat sheet, oxygen generating, 3D printed vascular devices
  • Small animal tumor models

Key Publications

  • In Vivo pO2 pO2 Assessment in Subcutaneous and Intraperitoneal Sites Using Imaging of Solid Oxygen Probes

    Tissue Engineering Part C: Methods, 2022

  • Amniotic growth factors enhanced human pre-adipocyte cell viability and differentiation under hypoxia

    Journal of Biomedical Materials Research Part B, 2022

  • A Bioinspired Scaffold for Rapid Oxygenation of Cell Encapsulation

    Nature Communications, 2021

  • An Inverse-Breathing Encapsulation System for Cell Delivery

    Science Advances, 2021

For a full list of our publications, see our Publications page

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