Did you know that BBB leakage can be quantified non-invasively with EPR Imaging?
In a healthy brain, the EPR imaging contrast agent, trityl OXO71, is blocked by the blood-brain barrier (BBB), but guess what, when the BBB is compromised because of any neurological issue, trityl can enter and light up the brain. Therefore, EPR imaging provides a straightforward way to image and quantify BBB when it's compromised. Moreover, when BBB is damaged, we can map three-dimensionally the brain partial oxygen pressure (pO2), which has not been explored before because of lack of technologies.
 The corresponding publication titled "Assessment of blood-brain barrier leakage and brain oxygenation in Connexin-32 knockout mice with systemic neuroinflammation using pulse electron paramagnetic resonance imaging techniques" was published in 2024 in Magnetic Resonance in Medicine (MRM) journal - (Volume 91, pages 2519-2531).
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