Webinars Archive

Dr Sally Pias | Molecular Modeling Changes How We Interpret EPR O2 Measurements

Recorded: November 11, 2021

About the webinar:

The locations of electron paramagnetic resonance (EPR) spin-label probes within a cellular or tissue microenvironment are generally unknown. However, EPR oxygen measurements are sensitive to the probe location, as oxygen itself partitions unevenly within cells and tissues. This talk will feature molecular modeling work that modifies interpretation of EPR oximetry data, with particular focus on membrane permeability as estimated using lipid-conjugated spin-label probes. (See our recent paper at https://rdcu.be/cxDel).

About the speaker:

Dr. Sally Pias is Associate Professor and Chair of Chemistry at the New Mexico Institute of Mining and Technology (New Mexico Tech, Socorro, NM, USA). She has a long-standing interest in oxygen transport within tissues and cells. Her group uses molecular dynamics simulations to investigate cellular biophysics, especially cell membrane effects on oxygen access to sites of interest inside cells.

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