Research services
Oxygen Measurement Core
O2M's Oxygen Measurement Core is a contract research facility offering comprehensive in vitro and small-animal in vivo oxygen measurement services.
All experiments use O2M's preclinical oxygen imager, the JIVA-25®, which accommodates samples up to 40 mm. The facility manages complete experimental cycles — from sample preparation and cell seeding through in vitro and in vivo oxygen imaging. Additional capabilities include biologic assays, histology, and publication-quality data and images for peer-reviewed submissions. We serve academic institutions, research foundations, and industry partners.
Discuss your projectExample projects
- In vitro longitudinal oxygen assessment of acellular and cell-loaded biomaterials, tissue grafts, and cell-encapsulation devices
- In vivo small-animal longitudinal assessment of biomaterials, tissue grafts, and cell-encapsulation devices
- In vivo oxygen assessment of tumor growth and treatment response
- In vivo quantification of blood-brain barrier leakage and brain pO₂
- Ex vivo oxygen imaging of transplanted organs for viability assessment
Example samples
- Biomaterials: gelatin, alginate, agarose, collagen, chitosan, PLGA, and experimental combinations
- Cell-encapsulation devices: flat sheet, oxygen-generating, 3D-printed vascular devices
- Small-animal tumor models
Key publications
- Accelerated EPR imaging using deep learning denoising
- Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
- Composite spin probes with adjustable oxygen sensitivity for pulse electron paramagnetic resonance imaging
- In Vivo Mouse Abdominal Oxygen Imaging and Assessment of Subcutaneously Implanted Beta Cell Replacement Devices
Current research collaborators
Viresh Rawal, PhD
University of Chicago
Harold Swartz, MD, PhD
Dartmouth (Geisel)
Periannan Kuppusamy, PhD
Dartmouth College
Moti Freiman, PhD
Technion
Marty Pagel, PhD
MD Anderson Cancer Center
Christopher D. Kroenke, PhD
Oregon Health & Science Univ.
Paul Buehler, PhD
CBOTH
Alan McMillan, PhD
Univ. of Wisconsin–Madison
Gal Shafirstein, PhD
Cell Stress Biology
Martyna Elas, PhD
Jagiellonian University
Joseph P. Y. Kao, PhD
Univ. of Maryland
Benoit Driesschaert, PhD
West Virginia University
Victoria Roberts, PhD
Oregon Health & Science Univ.
Gareth Eaton, PhD
University of Denver
Sandra Eaton, PhD
University of Denver
Past research collaborators
Carl Simon, PhD
NIST
Matthew Rosen, PhD
Harvard Medical School
Corinne Hoesli, PhD
McGill University
Yvonne Mowery, MD, PhD
University of Pittsburgh
Mathew Mathew, PhD
UIC School of Medicine
Joshua Biller, PhD
TDA Research, Inc.
Gregory M. Palmer, PhD
Duke University Medical Center
Dang Thuy Tram, PhD
Nanyang Tech. University
Ethics & governance
O2M maintains rigorous ethical standards across all activities. The organization and its research partners comply with applicable regulations and best practices for responsible animal research under AAALAC and AALAS guidelines. Operations include team training, quality assurance, and integrated data management, with transparency, conflict-of-interest disclosure, and adherence to Financial Conflict of Interest in Research policies for government-funded and sponsored projects.
Financial Conflict of Interest in Research (FCOIR) policy — view PDF