Development of Stable Triarylmethyl Radicals EPR
May 10, 2021
Low-field electron paramagnetic resonance (EPR) with a molecular spin probe is a powerful technique to profile various biomarkers of the tissue microenvironment in vivo. This presentation will discuss the design, synthesis, and applications of triarylmethyl (TAM) radicals sensitive to important physiological parameters such as dissolved oxygen concentration, pH, inorganic phosphate (Pi) concentration, microviscosity, and enzyme activity.
Dr. Benoit Driesschaert is an Organic Chemist, Assistant Professor at West Virginia University in the Department of Pharmaceutical Sciences. His laboratory develops stable triarylmethyl radicals used as spin probes and spin labels for biomedical EPR applications.