Our technology

EPROI Spin Probes

Trityl OXO63/OXO71

The oxygen imaging using EPROI requires contrast agent, trityl OXO63 or its deuterated version OXO71. OXO71 has many unbeatable qualities:

• Stable radicals
• Water soluble and non-toxic
• Single EPR line
• High SNR at physiologic settings
• Trityl is added in vitro (0.5 mM – 1 mM concentration)
• Trityl is injected systematically via I.V. or I.P. route in animals (150 µL – 300 µL of 72 mM stock solution). In tumors, trityl can also be injected via intra-tumoral injections
• Fast clearance from animals (10 – 30 min). No adverse effect reported from hundreds of animals imaged

Ball-and-stick model of OXO71³⁻. Carbon atoms are depicted in grey, hydrogen in white, deuterium in green, oxygen in red, and sulfur in gold.

← Back to Applications