Applications

Applications of EPR oxygen imaging

Tumor Hypoxia

Spatial heterogeneity in tumor hypoxia is the most important factor in regulating tumor growth, development, aggressiveness, metastasis, and effective treatment outcome. It has been known that most tumors are often characterized by hypoxia or low oxygen levels (pO₂ < 10 torr/mmHg). An accurate oxygen concentration is needed for Oxygen Guided Radiation Therapy (OGRT) to reduce the overall radiation dose. O2M's patented technology has been shown to be highly effective in measuring tiny voxels of hypoxic tumor.

Type 1 Diabetes (T1D)

T1D mellitus is an autoimmune disorder in which the body's immune response destroys the insulin-producing islet cells. Islet transplantation therapy has shown significant promise; however, the lack of oxygen supply to the highly metabolic islet cells is the major contributing factor to the failure of cell transplantation devices. Backed by JDRF, O2M team is helping researchers optimize islet cell replacement devices.

Biomaterials Assessment

Oxygen affects cell proliferation, differentiation, metabolism and apoptosis. Biomaterials have different oxygen diffusion profile based on their treatment. Oxygen monitoring in biomaterials and artificial tissues will avert hypoxia induced cell death, control cell differentiation, and overall improve the graft quality.

Learn More About Our Technology

Oxygen Imaging How EPROI works, EPR fundamentals, and how it differs from MRI
EPROI Spin Probes Trityl OXO63/OXO71 contrast agents and their properties
FAQ Answers to common questions about oxygen imaging, EPR, EPROI, and our instruments

O2M Technologies® Patents

For a list of our publications, see our Publications page.